南方医科大学热带医学研究所

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所长 陈晓光

发布时间:2021年10月11日 浏览次数:

“新世纪百千万人才工程”国家级人选、国务院特殊津贴专家,军队杰出人才基金获得者、优秀党员、优秀教师,广东省特聘教授珠江学者、广东省高校教学名师、南粤优秀教师、广东省新发传染病防治重点实验室主任,南方医科大学热带医学研究所所长、教授、博士生导师。

主持国家级精品课程、国家级双语示范课程、国家级精品视频公开课、教育部来华留学英语授课品牌课程、广东省研究生示范课程等多项教改项目;主编/副主编全国统编教材4部;发表教学论文10余篇包括南方医科大学首篇SCI教学论文;获军队“育才奖”银奖、中华医学会教育分会“医学教育优秀论文”二等奖1项;培养珠江学者1名、珠江科技新星1名、广州菁英计划获得者2名、广东省优秀青年教师1名、南医优秀教师3名;指导的本科生两次获得广东省大学生挑战杯二等奖以及首届全国大学生基础医学创新论坛暨实验设计大赛三等奖。

主持研究国内外重要课题10余项,包括WHO/TDR课题2项、美国NIH R01课题1项、国家自然科学基金重点类项目3项、国家重大科技攻关项目1项、国家863项目1项、军队杰出人才基金1项、广东省重大生物科技专项1项、广东省自然科学基金研究团队项目等。以第一完成人获得广东省科技进步二等奖2项、军队科技进步二等奖1项、南粤科技创新优秀论文一等奖1项;获发明专利授权4项、实用新型专利权3项;发表学术论文近200篇,其中包括发表在Science, PNAS, Lancet Infectious Disease, Genome Biology, PLoS Pathogen,Emerging Infectious Diseases, Advances in Genetics, Trendsin Parasitology上的SCI论文60多篇,被他引736次。

积极将多年来教学科研的成果指引疾病的防治。比如2014年广东省登革热大流行,作为该领域的专家不仅亲身投入到疾病防治的一线,积极为政府和相关的职能部门出谋划策,为蚊媒传染病的防治制定方案;还利用在国内外学术界的影响力,积极地在电视、报刊等新闻媒体上进行登革热防治的科普宣传,分别接受了《纽约时报》《华尔街日报》《环球时报》《凤凰周刊》《南方都市报》《广州电视台》等多家媒体的采访,承担了一个学者所应肩负的社会责任。另外,陈晓光还作为国家和广东省爱国卫生运动的专家,经常参与指导健康城市和卫生城市的创建和评审工作。

现担任中国动物学会原生动物学分会副理事长、中国动物学会寄生虫学专业委员会副理事长、中华医学会热带病与寄生虫学分会常务理事、中华预防医学会媒介生物学及控制学会理事、中国昆虫学会昆虫基因组学分会和医学昆虫分会理事、广东省有害生物防制协会会长、广东省热带医学会副理事长、广东省寄生虫学会副理事长、广东省预防医学会常委、广东省生物医学工程学会理事、广东省高性能计算学会理事、广东省新发传染病防治重点实验室主任、《南方医科大学学报》《中国病原生物学杂志》《寄生虫与医学昆虫学报》《Parasitology Research》编委等职务。

代表性著作

Jiayong Zhou#, Shuang Liu#, Hongkai Liu, Zhensheng Xie, Liping Liu, Lifeng Liu, Jinyong Jiang, Mingdong Yang, Guofa Zhou, Jinbao Gu, Xiaohong Zhou, Guiyan Yan, Anthony A. James, Xiao-Guang Chen*. Interspecific mating bias may drive Aedes albopictus displacement of Aedes aegypti during its range expansion. PNAS nexus. 2022, 1: 1-10.

Wenqiang Yang, Siyu Zhao, Yugu Xie, Tong Liu, Ling Kong, Yijia Guo, Zhensheng Xie, Peiwen Liu*, Xiao-Guang Chen*. Armigeres subalbatus is a potential vector for Zika virus but not dengue virus. Infect Dis Poverty, 2022, 11:62.

Ye Xu, Jingni Zhou, Tong Liu, Peiwen Liu, Yang Wu, Zetian Lai, Jinbao Gu, Xiao-Guang Chen*. Assessing the risk of spread of Zika virus under current and future climate scenarios. Biosafety and Health, 2022.

Jielin Deng#, Yijia Guo#, Xinghua Su, Shuang Liu, Wenqiang Yang, Yang Wu, Kun Wu, Guiyun Yan, Xiao-Guang Chen*. Impact of deltamethrin-resistance in Aedes albopictus on its fitness cost and vector competence. PLoS Neglected Tropical Diseases. 2021, 15(4):e0009391.

Tong Liu#, Yu-Gu Xie#, Feng Lin#, Li-Hua Xie#, Wen-Qiang Yang, Xing-Hua Su, Chun-Quan Ou, Lei Luo, Qi Xiao, Lu Gan and Xiao-Guang Chen*. A long-lasting biological larvicide against the dengue vector mosquito Aedes albopictus. Pest Manag Sci. 2021, (2):741-748.

Binbin Jin, Yijie Zhao, Yunqiao Dong, Peiwen Liu, Yan Sun, Xiaocong Li, Xin Zhang, Xiao-Guang Chen*, Jinbao Gu*. Alternative splicing patterns of doublesex reveal a missing link between Nix and doublesex in the sex determination cascade of Aedes albopictus. Insect Sci, 2021, 28(6):1601-1620.

Zetian Lai, Tengfei Zhou, Jiayong Zhou, Shuang Liu, Ye Xu, Jinbao Gu, Guiyun Yan, Xiao-Guang Chen*. Vertical Transmission of Zika Virus in Aedes albopictus. PLoS Negl Trop Dis. 2020, 14(10):e0008776.

Teng-Fei Zhou#, Ze-Tian Lai#, Shuang Liu, Jia-Yong Zhou, Yang Liu, Yang Wu, Ye Xu, Kun Wu, Jin-Bao Gu, Gong Cheng, Xiao-Guang Chen*.Susceptibility and interactions between Aedes mosquitoes and Zika viruses. Insect Sci. 2021, 28(5):1439-1451.

Longfei Chen#, David A Christian#, Joshua A Kochanowsky, Anthony T Phan, Joseph T Clark, Shuai Wang, Corbett Berry, Jung Oh, Xiaoguang Chen, David S Roos, Daniel P Beiting, Anita A Koshy, Christopher A Hunter*. The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses. J Exp Med. 2020, 2;217(3):e20181757.

Hongmei Liu*, Luhong Liu, Peng Cheng, Linlin Yang, Junhu Chen, Yao Lu, Haifang Wang, Xiao‑Guang Chen*, Maoqing Gong*. Bionomics and insecticide resistance of Aedes albopictus in Shandong, a high latitude and high-risk. Parasit Vectors. 2020, 9;13(1):11.

Lihua Xie, Wenqiang Yang, Hongmei Liu, Tong Liu, Yugu Xie, Feng Lin, Guofa Zhou, Xiaohong Zhou, Kun Wu, Jinbao Gu, Guiyun Yan, Xiao-Guang Chen*. Enhancing attraction of the vector mosquito Aedes albopictus by using a novel synthetic odorant. Parasit Vectors. 2019, 30;12(1):382.

Xinghua Su, Yijia Guo, Jielin Deng, Jiabao Xu, Guofa Zhou, Tengfei Zhou, Yiji Li, Daibin Zhong, Ling Kong, Xiaoming Wang, Min Liu, Kun Wu, Guiyun Yan, Xiao-Guang Chen*. Fast emerging insecticide resistance in Aedes albopictus in Guangzhou, China: Alarm to the dengue epidemic. PLoS Negl Trop Dis. 2019, 16;13(9):e0007665.

Peiwen Liu, Binbin Jin, Xiaocong Li, Yijie Zhao, Jinbao Gu, James K Biedler, Zhijian Jake Tu*, Xiao-Guang Chen*. Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus. Insect Biochem Mol Biol. 2020, 118:103311.

Min Liu, Fen-Xiang Li, Chun-Yuan Li, Xiao-Cong Li, Long-Fei Chen, Kun Wu, Pei-Liang Yang, Zhi-Fa Lai, Ting-Kai Liu, William J Sullivan Jr, Liwang Cui, Xiao-Guang Chen*. Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii. Parasit Vectors. 2019, 8;12(1):221.

Xiaocong Li, Binbin Jin, Yunqiao Dong, Xiaoguang Chen*, Zhijian Tu, Jinbao Gu*. Two of the three Transformer-2 genes are required for ovarian development in Aedes albopictus. Insect Biochem Mol Biol. 2019, 109:92-105.

Hongmei Liu*, Lihua Xie, Peng Cheng, Jiabao Xu, Xiaodan Huang, Haifang Wang, Xiao Song, Lijuan Liu, Huaiwei Wang, Jingxuan Kou, Guiyun Yan, Xiao-Guang Chen*, Maoqing Gong*. Trends in insecticide resistance in Culex pipiens pallens over 20 years in Shandong, China. Parasit Vectors. 2019, 11;12(1):167.

Yumin Qi#, Yang Wu#, Randy Saunders, Xiao-Guang Chen, Chunhong Mao, James Kite Biedler*, Zhijian Jake Tu*. Guy1, a Y-linked embryonic signal, regulates dosage compensation in Anopheles stephensi by increasing X gene expression. Elife. 2019, 19;8:e43570.

Tong Liu, Wen-Qiang Yang, Yu-Gu Xie, Pei-Wen Liu, Li-Hua Xie, Feng Lin, Chen-Ying Li, Jin-Bao Gu, Kun Wu, Gui-Yun Yan, Xiao-Guang Chen*. Construction of an efficient genomic editing system with CRISPR/Cas9 in the vector mosquito Aedes. Insect Sci. 2019, 26(6):1045-1054.

Yang Wu, Wanqi Hu, James K Biedler , Xiao-Guang Chen*, Zhijian Jake Tu*. Pure early zygotic genes in the Asian malaria mosquito Anopheles stephensi. Parasit Vectors. 2018, 24;11(Suppl 2):652.

Jiabao Xu, Xinghua Su, Mariangela Bonizzoni, Daibin Zhong, Yiji Li, Guofa Zhou, Hoan Nguyen, Sarah Tong, Guiyun Yan, Xiao-Guang Chen*. Comparative transcriptome analysis and RNA interference reveal CYP6A8 and SNPs related to pyrethroid resistance in Aedes albopictus. PLoS Negl Trop Dis. 2018, 12;12(11):e0006828.

Lin Dechun#, Li Liqiang#*, Xie Tian, Yin Qingqing, Saksena Nitin, Wu Rangke, Li Wanyu, Dai Geyang, Ma Jinmin*, Zhou Xiaohong*, Chen Xiaoguang*; Codon usage variation of Zika virus: The potential roles of NS2B and NS4A in its global pandemic, Virus Research. 2018, 247: 71-83.

Yiji Li, Jiabao Xu, Daibin Zhong, Hong Zhang, Wenqiang Yang, Guofa Zhou, Xinghua Su, Yang Wu, Kun Wu, Songwu Cai, Guiyun Yan*, Xiao-Guang Chen*. Evidence for multiple-insecticide resistance in urban Aedes albopictus populations in southern China.Parasites & Vectors. 2018, 11:4.

Xiaoming Wang, Tong Liu, Yang Wu, Daibin Zhong, Guofa Zhou, Xinghua Su, Jiabao Xu, Charity F. Sotero, Adnan A. Sadruddin, Kun Wu*, Xiao-Guang Chen*, Guiyun Yan*. Bacterial microbiota assemblage in Aedes albopictus mosquitoes and its impacts on larval development. Molecular Ecology. 2018, 27:2972-2985.

Zhuanzhuan Liu#, Zhenhong Zhang#, Zetian Lai, Tengfei Zhou, Zhirong Jia, Jinbao Gu, Kun Wu, Xiao-Guang Chen*. Temperature increase enhances Aedes albopictus competence to transmit dengue virus. Front Microbiol. 2017, 8:2337.

Peiwen Liu, Yunqiao Dong, Jinbao Gu*, Santhosh Puthiyakunnon, Yang Wu, Xiao-Guang Chen*. Developmental piRNA profiles of the invasive vector mosquito Aedes albopictus. Parasite & Vectors. 2016, 9:524.

Yiji Li, Xinghua Su, Guofa Zhou, Hong Zhang, Santhosh Puthiyakunnon, Shufen Shuai, Songwu Cai, Jinbao Gu, Xiaohong Zhou, Guiyun Yan, Xiao-Guang Chen*. Comparative evaluation of the efficiency of the BG-Sentinel trap, CDC light trap and Mosquito-oviposition trap for the surveillance of vector mosquitoes. Parasites & Vectors. 2016, 9:446. 

Jiabao Xu, Mariangela Bonizzoni, Daibin Zhong, Guofa Zhou, Songwu Cai, Yiji Li, Xiaoming Wang, Eugenia Lo, Rebecca Lee, Roger Sheen, Jinhua Duan, Guiyun Yan*, Xiao-Guang Chen*. Multi-country survey revealed prevalent and novel F1534S mutation in voltage-gated sodium channel (VGSC) gene in Aedes albopictus. PLoS Negl Trop Dis. 2016, 10(5):e0004696.

Xiao-Guang Chen*, Xuanting Jiang, Jinbao Gu, Meng Xu, Yang Wu, Yuhua Deng, Chi Zhang, Mariangela Bonizzoni, Wannes Dermauw, John Vontas, Peter Armbruster, Xin Huang, Yulan Yang, Hao Zhang, Weiming He, Hongjuan Peng, Yongfeng Liu, Kun Wu, Jiahua Chen, Manolis Lirakis, Pantelis Topalis, Thomas Van Leeuwen, Andrew Brantley Hall, Xiaofang Jiang, Chevon Thorpe, Rachel Lockridge Mueller, Cheng Sun, Robert Michael Waterhouse, Guiyun Yan, Zhijian Jake Tu, Xiaodong Fang*, Anthony A James*. Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution. Proc Natl Acad Sci U S A. 2015, 112(44):E5907-15.

主持或参加科研项目

1.国家重点研发项目,重要外来入侵蚊虫监测和控制关键技术产品研究

2.国家自然科学基金委(重点项目),重要媒介蚊虫昼夜节律的分子调控机制

3.国家自然科学基金委登革热媒介白纹伊蚊的杀虫剂抗性研究

4.美国NIH,Impacts of Urbanization on Vector Biology and Transmission of Dengue in China

5.广州市科技创新委员会,白纹伊蚊新型监测和控制体系的研制和应用

6.国家重点研发计划,入侵媒介和病原体/病原体与宿主(媒介)相互作用的分子机制研究

7.广州市健康医疗协同创新重大专项分题,广州登革热流行的病原学、媒介控制控制与临床救治研究

8.广东省科技计划联合攻关项目基金,广东省寨卡病毒病流行风险预警及应对研究

9.广东省自然科学基金研究团队项目,重要媒介蚊虫防制的基础与应用研究

10.国家自然科学基金(国际(地区)合作与交流项目),白蚊伊蚊雄性决定基因的筛选鉴定和功能研究